Vicoprofen

Generic Name: hydrocodone and ibuprofen (Oral route)

hye-droe-KOE-done bye-TAR-trate, eye-bue-PROE-fen

Commonly used brand name(s)

In the U.S.

• Ibudone


• Reprexain


• Vicoprofen

Available Dosage Forms:

• Tablet

Therapeutic Class: Opioid/NSAID Combination

Pharmacologic Class: NSAID

Chemical Class: Hydrocodone

Uses For Vicoprofen

Hydrocodone and ibuprofen combination is used to relieve acute pain. This medicine should only be used for short periods of time, usually for a total of less than 10 days. This combination is not used for osteoarthritis or rheumatoid arthritis.

Hydrocodone is a narcotic analgesic that acts on the central nervous system to relieve pain. If hydrocodone is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to withdrawal side effects when you stop taking the medicine. Since hydrocodone and ibuprofen combination is only used for short-term (10 days or less) relief of pain, physical dependence will probably not occur.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used in this combination to relieve inflammation, swelling, and pain.

This medicine is available only with your doctor's prescription.

Before Using Vicoprofen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of hydrocodone and ibuprofen combination in children and teenagers below 16 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrocodone and ibuprofen combination in the elderly. However, elderly patients are more likely to develop age-related kidney or stomach problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Naltrexone


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Adinazolam


• Alfentanil


• Alprazolam


• Amobarbital


• Anileridine


• Aprobarbital


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Bromazepam


• Brotizolam


• Buprenorphine


• Butabarbital


• Butalbital


• Butorphanol


• Carisoprodol


• Certoparin


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Cilostazol


• Citalopram


• Clobazam


• Clonazepam


• Clopidogrel


• Clorazepate


• Clovoxamine


• Codeine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Dantrolene


• Desirudin


• Dezocine


• Diazepam


• Dipyridamole


• Enoxaparin


• Escitalopram


• Estazolam


• Ethchlorvynol


• Femoxetine


• Fentanyl


• Flesinoxan


• Flunitrazepam


• Fluoxetine


• Flurazepam


• Fluvoxamine


• Fondaparinux


• Fospropofol


• Ginkgo


• Halazepam


• Heparin


• Hydrocodone


• Hydromorphone


• Ketazolam


• Lepirudin


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Methotrexate


• Midazolam


• Morphine


• Morphine Sulfate Liposome


• Nadroparin


• Nalbuphine


• Nefazodone


• Nitrazepam


• Nordazepam


• Opium


• Oxazepam


• Oxycodone


• Oxymorphone


• Parnaparin


• Paroxetine


• Pemetrexed


• Pentazocine


• Pentobarbital


• Phenobarbital


• Prazepam


• Propoxyphene


• Protein C


• Quazepam


• Remifentanil


• Reviparin


• Rivaroxaban


• Secobarbital


• Sertraline


• Sibutramine


• Sodium Oxybate


• Sufentanil


• Tacrolimus


• Tapentadol


• Temazepam


• Thiopental


• Ticlopidine


• Tinzaparin


• Tirofiban


• Triazolam


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amikacin


• Amiloride


• Arotinolol


• Aspirin


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desipramine


• Desvenlafaxine


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Escitalopram


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Phenytoin


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Tacrine


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Voriconazole


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Addison's disease (adrenal gland problem) or


• Enlarged prostate (BPH, prostatic hypertrophy) or


• Hypothyroidism (underactive thyroid) or


• Kidney disease, severe or


• Liver disease, severe or


• Problems with urination or


• Systemic lupus erythematosus (SLE) or


• Weakened physical condition—Use with caution. May increase risk for more serious side effects.

• Anemia or


• Bleeding problems or


• Breathing problems (e.g., respiratory depression) or


• Edema (fluid retention) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• Hypertension (high blood pressure) or


• Kidney disease or


• Liver disease or


• Lung disease or


• Stomach ulcers or bleeding, history of or


• Stroke, history of—Use with caution. May make these conditions worse.

• Aspirin-sensitive asthma or


• Aspirin sensitivity, history of—Should not be used in patients with these conditions.

• Drug abuse or dependence, or history of—Dependence may be more likely to develop.

• Heart surgery (e.g., coronary artery bypass graft [CABG])—Should not be used to relieve pain right before or after the surgery.

Proper Use of hydrocodone and ibuprofen

This section provides information on the proper use of a number of products that contain hydrocodone and ibuprofen. It may not be specific to Vicoprofen. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For pain:
    
    • Adults and teenagers above 16 years of age—One tablet every 4 to 6 hours as needed. However, the dose is usually not more than 5 tablets per day.
    
    
    • Children and teenagers younger than 16 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Vicoprofen

It is very important that your doctor check your progress while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine may increase your risk of having a heart attack or stroke. This is more likely to occur in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Some signs of serious heart problems are chest pain, tightness in the chest, fast or irregular heartbeat, or unusual flushing or warmth of the skin. Stop taking this medicine and check with your doctor right away if you notice any of these warning signs.

This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely to occur if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as steroids or a blood thinner). Call your doctor right away if you have severe stomach pain; black, tarry stools; or are vomiting blood or material that looks like coffee grounds.

Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you have more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; a severe skin rash or acne; sores or ulcers on the skin; or fever or chills while you are using this medicine.

Using this medicine during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Hydrocodone and ibuprofen combination will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, sleeping medicine; or other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your medical doctor or dentist before taking any of the medicines listed above while you are using this medicine.

This medicine may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If these reactions are especially bothersome, check with your doctor.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Hydrocodone and ibuprofen combination may cause dry mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if you take this medicine for a long time and dry mouth continues for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Call your doctor right away if you have confusion, drowsiness, fever, a general feeling of illness, a headache, loss of appetite, nausea, a stiff neck or back, or vomiting. These could be symptoms of a serious condition called meningitis.

If you have heart disease or congestive heart failure (CHF), tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.

Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Vicoprofen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

• Bloody stools


• burning feeling in the chest or stomach


• congestion in the chest


• changes in facial skin color


• cough


• diarrhea


• difficulty with swallowing


• fast or irregular breathing


• fever


• frequent urge to urinate


• heartburn


• inability to urinate


• irregular heartbeat


• lightheadedness or dizziness


• loss of bladder control


• puffiness or swelling of the eyelids or around the eyes


• ringing or buzzing in the ears


• shortness of breath, troubled breathing, tightness in the chest or wheezing


• skin rash, hives, or itching


• stomach pain


• tenderness in the stomach

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Blurred vision


• cold or clammy skin


• confusion


• difficulty hearing or ringing or buzzing in the ears


• dizziness


• general feeling of illness


• headache


• mood or mental changes


• nausea or vomiting


• severe drowsiness


• severe stomach pain


• skin rash


• slow heartbeat


• slow or troubled breathing


• stiff neck or back


• swelling of the face, fingers, feet, or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Anxiety


• constipation


• dry mouth


• gas


• increased sweating


• nervousness


• pounding heartbeat


• sleepiness


• trouble in sleeping


• unusual tiredness or weakness

Less common or rare

• Decreased appetite


• decrease in sexual ability


• depression


• headache


• heartburn


• increased thirst


• irritability


• mood or mental changes


• mouth ulcers


• pain or burning in the throat


• runny nose


• sensation of burning, warmth, heat, numbness, tightness, or tingling


• slurred speech


• stomach upset


• thinking abnormalities


• trembling or shaking of the hands or feet


• unexplained weight loss


• unusual feeling of well-being


• visual disturbances

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Vicoprofen side effects (in more detail)

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More Vicoprofen resources

• Vicoprofen Side Effects (in more detail)
• Vicoprofen Dosage
• Vicoprofen Use in Pregnancy & Breastfeeding
• Drug Images
• Vicoprofen Drug Interactions
• Vicoprofen Support Group
• 29 Reviews for Vicoprofen - Add your own review/rating

• Vicoprofen Consumer Overview


• Vicoprofen MedFacts Consumer Leaflet (Wolters Kluwer)


• Vicoprofen Prescribing Information (FDA)


• Ibudone Prescribing Information (FDA)


• Reprexain Prescribing Information (FDA)

Compare Vicoprofen with other medications

• Pain

Amaryl

Generic Name: glimepiride (glye MEP ir ide)

Brand Names: Amaryl

What is glimepiride?

Glimepiride is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Glimepiride is used together with diet and exercise to treat type 2 diabetes. Insulin or other diabetes medicines are sometimes used in combination with glimepiride if needed.

Glimepiride may also be used for purposes not listed in this medication guide.

What is the most important information I should know about glimepiride?

Do not use this medication if you are allergic to glimepiride, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glimepiride, tell your doctor if you are allergic to sulfa drugs, or if you have heart disease, liver disease, kidney disease, an enzyme deficiency (G6PD), adrenal or pituitary gland problems, or if you are under-nourished.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Glimepiride is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

What should I discuss with my doctor before taking glimepiride?

You should not use this medication if you are allergic to glimepiride or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take glimepiride, tell your doctor if you have any of these other conditions:

• heart disease;


• liver or kidney disease;


• 
  

  an allergy to sulfa drugs;

  
  


• 
  

  an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

  
  


• 
  

  adrenal or pituitary gland problems; or

  
  


• 
  

  if you are under-nourished.

  
  

FDA pregnancy category C. It is not known whether glimepiride will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether glimepiride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take glimepiride?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Glimepiride is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take glimepiride with a full glass of water. Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your glimepiride dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Glimepiride is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Store at room temperature away from moisture and heat.

See also: Amaryl dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Use glimepiride regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glimepiride overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, trouble speaking, blurred vision, nausea, fainting, and seizure (convulsions).

What should I avoid while taking glimepiride?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Avoid exposure to sunlight or tanning beds. Glimepiride can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Glimepiride side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  severe skin rash, itching, redness, or irritation;

  
  


• 
  

  pale skin, easy bruising or bleeding, fever, unusual weakness;

  
  


• 
  

  numbness or tingly feeling;

  
  


• 
  

  trouble breathing;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  dark urine, clay-colored stools;

  
  


• 
  

  upper stomach pain, low fever, jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  nausea, vomiting, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.

  
  

Less serious side effects may include:

• 
  

  dizziness, headache, tired feeling;

  
  


• 
  

  mild nausea, vomiting, stomach pain, diarrhea;

  
  


• 
  

  increased skin sensitivity to sunlight; or

  
  


• 
  

  mild itching or skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect glimepiride?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• 
  

  albuterol (Proventil, Ventolin);

  
  


• 
  

  clonidine (Catapres);

  
  


• 
  

  reserpine;

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

  
  

You may be more likely to have hypoglycemia (low blood sugar) if you take glimepiride with:

• 
  

  clarithromycin (Biaxin);

  
  


• 
  

  disopyramide (Norpace);

  
  


• 
  

  exenatide (Byetta);

  
  


• 
  

  fluoxetine (Prozac, Sarafem);

  
  


• 
  

  probenecid (Benemid);

  
  


• 
  

  an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), and others;

  
  


• 
  

  some nonsteroidal anti-inflammatory drugs (NSAIDs);

  
  


• 
  

  aspirin or other salicylates (including Pepto-Bismol);

  
  


• a blood thinner (warfarin, Coumadin and others);


• 
  

  a monoamine oxidase inhibitor (MAOI);

  
  


• 
  

  sulfa drugs (Bactrim, Gantanol, Septra, and others); or

  
  


• 
  

  other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

  
  

You may be more likely to have hyperglycemia (high blood sugar) if you take glimepiride with:

• 
  

  isoniazid;

  
  


• 
  

  diuretics (water pills);

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  niacin (Advicor, Niaspan, Niacor, Niaspan, Simcor, Slo-Niacin, and others);

  
  


• 
  

  phenothiazines (Compazine and others);

  
  


• 
  

  thyroid medicine (Synthroid and others);

  
  


• 
  

  birth control pills and other hormones;

  
  


• 
  

  seizure medicines (Dilantin and others);

  
  


• 
  

  diet pills; and

  
  


• 
  

  medicines to treat asthma, colds or allergies.

  
  

These lists are not complete and there are many other medicines that can increase or decrease the effects of glimepiride on lowering your blood sugar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Amaryl resources

• Amaryl Side Effects (in more detail)
• Amaryl Dosage
• Amaryl Use in Pregnancy & Breastfeeding
• Drug Images
• Amaryl Drug Interactions
• Amaryl Support Group
• 7 Reviews for Amaryl - Add your own review/rating

• Amaryl Prescribing Information (FDA)


• Amaryl Consumer Overview


• Amaryl Monograph (AHFS DI)


• Amaryl MedFacts Consumer Leaflet (Wolters Kluwer)


• Amaryl Advanced Consumer (Micromedex) - Includes Dosage Information


• Glimepiride Prescribing Information (FDA)


• Glimepiride Professional Patient Advice (Wolters Kluwer)

Compare Amaryl with other medications

• Diabetes, Type 2

Where can I get more information?

• Your pharmacist can provide more information about glimepiride.

See also: Amaryl side effects (in more detail)

anti-inhibitor coagulant complex Intravenous

AN-tee in-HIB-i-ter co-AG-yoo-lant kom-plex

Intravenous route(Powder for Solution)

Thrombotic and thromboembolic events have been reported during post-marketing surveillance following infusion of anti-inhibitor coagulation complex, vapor heated (VH) or anti-inhibitor coagulation complex, nanofiltered (NF), particularly following the administration of high doses and/or in patients with thrombotic risk factors .

Commonly used brand name(s)

In the U.S.

• Autoplex T


• Feiba NF


• Feiba-VH

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antihemophilic Agent

Uses For anti-inhibitor coagulant complex

Anti-inhibitor coagulant complex injection is used to control bleeding episodes or bleeding during surgery in patients with hemophilia A and hemophilia B.

Anti-inhibitor coagulant complex contains substances called coagulation factors (e.g., non-activated Factors II, IX, and X, and activated Factor VII) that are normally produced in the body. These substances are used to stop bleeding of injuries for patients with hemophilia by helping the blood to clot.

anti-inhibitor coagulant complex is to be administered only by or under the supervision of your doctor.

Before Using anti-inhibitor coagulant complex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For anti-inhibitor coagulant complex, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to anti-inhibitor coagulant complex or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of anti-inhibitor coagulation complex injection in newborn babies. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of anti-inhibitor coagulation complex injection in geriatric patients. However, it should be used with caution in elderly patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving anti-inhibitor coagulant complex, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using anti-inhibitor coagulant complex with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aminocaproic Acid


• Tranexamic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of anti-inhibitor coagulant complex. Make sure you tell your doctor if you have any other medical problems, especially:

• Atherosclerosis (hardening of the arteries) or


• Blood clotting problems (e.g., venous thrombosis, pulmonary embolism) or history of or


• Heart attack, history of or


• Injury, serious or


• Septicemia (serious blood infection) or


• Stroke, history of—Use with caution. May increase the risk of a blood clot.

• Bleeding problems caused by coagulation factor VIII or coagulation factor IX deficiencies or


• Disseminated intravascular coagulation or DIC (blood clotting problem) or


• Fibrinolysis or


• If your blood clots normally—Should not be used in patients with these conditions.

• Coronary heart disease, history of or


• Liver disease (including hepatitis A) or


• Parvovirus B19 infection or


• Weak immune system—Use with caution. May make these conditions worse.

• Non-hemophilic patients (who have acquired inhibitors against Factors VIII, IX, or XII)—May increased risk for both bleeding and blood clotting problems.

Proper Use of anti-inhibitor coagulant complex

A doctor or other trained health professional will give you anti-inhibitor coagulant complex. anti-inhibitor coagulant complex is given through a needle placed in one of your veins.

Precautions While Using anti-inhibitor coagulant complex

It is very important that your doctor check you closely while you are receiving anti-inhibitor coagulant complex to make sure it is working properly. Blood tests may be needed to check for unwanted effects.

anti-inhibitor coagulant complex may increase your chance of having blood clots or bleeding, especially in patients with atherosclerosis (hardening of the arteries), injury, a serious blood infection (septicemia), or a history of blood clotting problems, heart attack, or stroke. Patients who stay in bed for a long time because of surgery or illness are also at risk for blood clots. Check with your doctor right away if you suddenly have chest pain, shortness of breath, a severe headache, leg pain, or problems with vision, speech, or walking.

anti-inhibitor coagulant complex may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble with breathing; trouble with swallowing; lightheadedness or dizziness; or any swelling of your hands, face, or mouth after you have receive anti-inhibitor coagulant complex.

anti-inhibitor coagulant complex is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the making of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Stop using anti-inhibitor coagulant complex and check with your doctor right away if you have chest pain, cough, fast or slow heartbeat, shortness of breath, trouble with breathing, or wheezing after receiving anti-inhibitor coagulant complex.

Check with your doctor right away if you develop pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor right away if you have fever, chills, drowsiness, joint pain, rash, or runny nose.

Certain components of the packaging material contain dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you start using anti-inhibitor coagulant complex.

anti-inhibitor coagulant complex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain or discomfort


• cough


• difficulty with swallowing


• dizziness


• fast heartbeat


• fever


• hives or welts


• hoarseness


• irritation


• itching


• joint pain, stiffness, or swelling


• nausea


• pain in the injection site


• pain or discomfort in the arms, jaw, back, or neck


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness of the skin


• shortness of breath


• skin rash


• sweating


• swelling of the eyelids, face, lips, hands, or feet


• tightness in the chest


• troubled breathing or swallowing


• unusual tiredness or weakness


• vomiting


• wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: anti-inhibitor coagulant complex Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More anti-inhibitor coagulant complex Intravenous resources

• Anti-inhibitor coagulant complex Intravenous Side Effects (in more detail)
• Anti-inhibitor coagulant complex Intravenous Use in Pregnancy & Breastfeeding
• Anti-inhibitor coagulant complex Intravenous Drug Interactions
• Anti-inhibitor coagulant complex Intravenous Support Group
• 0 Reviews for Anti-inhibitor coagulant complex Intravenous - Add your own review/rating

Compare anti-inhibitor coagulant complex Intravenous with other medications

• Hemophilia A

Multi-Symptom Nighttime Cold & Flu Relief (cherry)

Generic Name: acetaminophen, dextromethorphan, and doxylamine (a SEET a MIN oh fen, DEX tro me THOR fan, and dox IL a meen)

Brand Names: All-Nite, Coricidin HBP Nighttime Multi-Symptom Cold, Cough & Sore Throat Nighttime, Delsym Nighttime Cough & Cold, Multi-Symptom Nighttime Cold & Flu Relief, Multi-Symptom Nighttime Cold & Flu Relief (cherry), Night Time Cold/Flu, Nite Time Cold & Flu, Nite Time Cold & Flu Relief, Nyquil Cold & Flu, NyQuil Cold/Flu Relief, NyQuil Cold/Flu Relief Cherry, Tylenol Cold & Cough Nighttime Cool Burst, Tylenol Cough & Sore Throat Night Time, Tylenol Warming Cough & Sore Throat Nightime

What is Multi-Symptom Nighttime Cold & Flu Relief (cherry) (acetaminophen, dextromethorphan, and doxylamine)?

Acetaminophen is a pain reliever and fever reducer.

Doxylamine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

The combination of acetaminophen, doxylamine, and dextromethorphan is used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.

This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, doxylamine, and dextromethorphan may also be used for purposes not listed in this medication guide.

What is the most important information I should know about this medicine?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of doxylamine. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What should I discuss with my healthcare provider before taking this medicine?

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;

  
  


• 
  

  a blockage in your digestive tract (stomach or intestines);

  
  


• 
  

  kidney disease;

  
  


• 
  

  cough with mucus, or cough caused by emphysema or chronic bronchitis;

  
  


• 
  

  enlarged prostate or urination problems; or

  
  


• 
  

  if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

  
  

It is not known whether acetaminophen, doxylamine, and dextromethorphan will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant. Acetaminophen, doxylamine, and dextromethorphan may pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Artificially sweetened cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take this medicine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking this medicine?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of doxylamine. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

This medicine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain, rapid pulse;

  
  


• 
  

  fast, slow, or uneven heart rate;

  
  


• 
  

  severe dizziness or anxiety, feeling like you might pass out;

  
  


• 
  

  severe headache;

  
  


• 
  

  mood changes, confusion, hallucinations, severe nervousness;

  
  


• 
  

  tremor, seizure (convulsions);

  
  


• 
  

  fever, easy bruising or bleeding, unusual weakness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness, mild headache;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  constipation, diarrhea, mild nausea, upset stomach;

  
  


• 
  

  blurred vision;

  
  


• 
  

  feeling restless or irritable; or

  
  


• 
  

  sleep problems (insomnia).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect this medicine?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by doxylamine.

Ask a doctor or pharmacist if it is safe for you to use acetaminophen, doxylamine, and dextromethorphan if you are also using any of the following drugs:

• 
  

  leflunomide (Arava);

  
  


• 
  

  topiramate (Topamax);

  
  


• 
  

  zonisamide (Zonegran);

  
  


• 
  

  an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;

  
  


• 
  

  an antidepressant;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  bladder or urinary medications;

  
  


• 
  

  blood pressure medication;

  
  


• 
  

  a bronchodilator;

  
  


• 
  

  cancer medicine;

  
  


• 
  

  cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;

  
  


• 
  

  gout or arthritis medications (including gold injections);

  
  


• 
  

  HIV/AIDS medication;

  
  


• 
  

  medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders;

  
  


• 
  

  an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or

  
  


• 
  

  seizure medication.

  
  

This list is not complete and there may be other drugs that can affect acetaminophen, dextromethorphan, and doxylamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Multi-Symptom Nighttime Cold & Flu Relief (cherry) resources

• Multi-Symptom Nighttime Cold & Flu Relief (cherry) Side Effects (in more detail)
• Multi-Symptom Nighttime Cold & Flu Relief (cherry) Use in Pregnancy & Breastfeeding
• Multi-Symptom Nighttime Cold & Flu Relief (cherry) Drug Interactions
• Multi-Symptom Nighttime Cold & Flu Relief (cherry) Support Group
• 0 Reviews for Multi-Symptom Nighttime (cherry) - Add your own review/rating

Compare Multi-Symptom Nighttime Cold & Flu Relief (cherry) with other medications

• Cough
• Pain

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen, dextromethorphan, and doxylamine.

See also: Multi-Symptom Nighttime (cherry) side effects (in more detail)

Humalog Mix 75/25 Pen

Generic Name: insulin lispro and insulin lispro protamine (IN soo lin LISS pro and IN soo lin LISS pro PRO ta meen)

Brand Names: HumaLOG Mix 50/50, HumaLOG Mix 50/50 KwikPen, HumaLOG Mix 50/50 Pen, HumaLOG Mix 75/25, HumaLOG Mix 75/25 KwikPen, HumaLOG Mix 75/25 Pen

What is Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin lispro is a fast-acting form of insulin. Insulin lispro protamine is an intermediate-acting form of insulin.

Insulin lispro and insulin lispro protamine is used to treat type 1 diabetes in adults. It is usually given together with another long-acting insulin.

Insulin lispro and insulin lispro protamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Use this medication within 15 minutes before eating a meal.

Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Signs of blood sugar that is too high (hyperglycemia) may include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your insulin dose.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

What should I discuss with my healthcare provider before using Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Do not use this medication if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure you can safely use insulin lispro and insulin lispro protamine, tell your doctor if you have liver or kidney disease.

Tell your doctor about all other medications you use, including any oral (by mouth) diabetes medications.

Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether insulin lispro and insulin lispro protamine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Insulin is injected under the skin. You will be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use this medication within 15 minutes before eating a meal.

Insulin lispro and insulin lispro protamine should appear cloudy after mixing. Do not use the medication if it has changed colors or has any particles in it. Return the medication to your pharmacy for a new supply.

Use a different place on your injection skin area each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

Ask your doctor how to adjust your insulin dose if needed. Do not change your medication dose or schedule without your doctor's advice. Wear a medical alert tag or carry an ID card stating that you have diabetes. Any medical care provider who treats you should know that you are diabetic. Storing unopened vials or injection pens: Keep in the carton and store in a refrigerator, protected from light. Throw away any insulin not used before the expiration date on the medicine label. Unopened vials may also be stored at room temperature for up to 28 days, away from heat and bright light. Throw away any insulin not used within 28 days. Unopened injection pens may also be stored at room temperature for up to 10 days, away from heat and bright light. Throw away any insulin not used within 10 days. Storing after your first use: You may keep "in-use" vials in the refrigerator, protected from light. Use within 28 days. Do not refrigerate an in-use injection pen. Keep it at room temperature and use within 10 days.

Do not freeze insulin lispro and insulin lispro protamine, and throw away the medication if it has become frozen.

What happens if I miss a dose?

Since this medication is used before meals, you may not be on a timed dosing schedule. Whenever you use insulin lispro and insulin lispro protamine, be sure to eat a meal within 15 minutes. Do not use extra insulin lispro and insulin lispro protamine to make up a missed dose.

Keep insulin lispro and insulin lispro protamine on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What should I avoid while using Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Do not change the brand of insulin lispro and insulin lispro protamine or syringe you are using without first talking to your doctor or pharmacist. Avoid drinking alcohol. It can lower your blood sugar. Do not expose insulin lispro and insulin lispro protamine to high heat.

Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine) side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Insulin lispro and insulin lispro protamine can also cause hypokalemia (low potassium levels in the blood). Call your doctor at once if you have symptoms such as confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin lispro and insulin lispro protamine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Humalog Mix 75/25 Pen (insulin lispro and insulin lispro protamine)?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• 
  

  albuterol (Proventil, Ventolin);

  
  


• 
  

  clonidine (Catapres);

  
  


• 
  

  reserpine; or

  
  


• 
  

  beta-blockers such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

  
  

There are many other medicines that can increase or decrease the effects of insulin lispro and insulin lispro protamine on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Humalog Mix 75/25 Pen resources

• Humalog Mix 75/25 Pen Side Effects (in more detail)
• Humalog Mix 75/25 Pen Use in Pregnancy & Breastfeeding
• Humalog Mix 75/25 Pen Drug Interactions
• Humalog Mix 75/25 Pen Support Group
• 0 Reviews for Humalog Mix 75/25 Pen - Add your own review/rating

• HumaLog Mix 50/50 Vials MedFacts Consumer Leaflet (Wolters Kluwer)


• Humalog Mix 50/50 Pens MedFacts Consumer Leaflet (Wolters Kluwer)


• Humalog Mix 50/50 Advanced Consumer (Micromedex) - Includes Dosage Information


• Humalog Mix 75/25 Prescribing Information (FDA)

Compare Humalog Mix 75/25 Pen with other medications

• Diabetes, Type 1
• Diabetes, Type 2

Where can I get more information?

• Your pharmacist can provide more information about insulin lispro and insulin lispro protamine.

See also: Humalog Mix 75/25 Pen side effects (in more detail)

NataFort Tablets

Dosage Form: tablet
NataFort®

PRENATAL MULTIVITAMIN TABLET WITH IRON

NataFort Tablets Description

NataFort® is a prescription prenatal/postnatal multivitamin/mineral supplement. The tablet is white, coated, and oval in shape, and is debossed "N1" on one side and is blank on the other.

Each prenatal tablet contains:
Vitamin C (Ascorbic acid)	120 mg
Vitamin D3 (Cholecalciferol)	400 IU
Vitamin E (dl-alpha tocoperyl acetate)	11 IU
Thiamin (Vitamin B1)	2 mg
Riboflavin (Vitamin B2)	3 mg
Niacinamide (Vitamin B3)	20 mg
Vitamin B6 (Pyridoxine HCl)	10 mg
Folic Acid	1 mg
Vitamin B12 (Cyanocobalamin)	12 mcg
Iron (Ferrous fumarate, carbonyl iron)	60 mg

INDICATIONS

NataFort® is a multivitamin/mineral prescription drug indicated for use in improving the nutritional status of women prior to conception, throughout pregnancy, and in the postnatal period for both lactating and nonlactating mothers.

Contraindications

This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.

WARNING

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF THE REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.

Warning

Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.

Precautions

Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress.

Adverse Reactions

Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

NataFort Tablets Dosage and Administration

One tablet daily or as directed by a physician.

Store at controlled room temperature.

NOTICE: Contact with moisture can discolor or erode the tablet.

How is NataFort Tablets Supplied

Bottles of 90 tablets each - NDC 0178-0716-90.

US Patent 6,521,247

MISSION PHARMACAL COMPANY

San Antonio, TX USA 78230 1355

Copyright © 2011 Mission Pharmacal Company.

All rights reserved.

L071690 C01 Rev 005110

PRINCIPAL DISPLAY PANEL - 90 Tablet Bottle Label

NDC 0178-0716-90

NataFort®

PRENATAL MULTIVITAMIN TABLET WITH IRON

For use before, during and after pregnancy

90 Tablets

Rx Only

Mission®

PHARMACAL

US Patent 6,521,247

NATAFORT  ascorbic acid, cholecalciferol, .alpha.-tocopherol acetate, dl-, thiamine mononitrate, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, cyanocobalamin, and iron  tablet

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0178-0716 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Ascorbic acid (Ascorbic acid) Ascorbic acid 120 mg Cholecalciferol (Cholecalciferol) Cholecalciferol 400 [iU] .alpha.-tocopherol acetate, dl- (.alpha.-tocopherol acetate, dl-) .alpha.-tocopherol acetate, dl- 11 [iU] Thiamine mononitrate (Thiamine) Thiamine mononitrate 2 mg Riboflavin (Riboflavin) Riboflavin 3 mg Niacinamide (Niacinamide) Niacinamide 20 mg Pyridoxine Hydrochloride (Pyridoxine) Pyridoxine Hydrochloride 10 mg Folic Acid (Folic Acid) Folic Acid 1 mg Cyanocobalamin (Cyanocobalamin) Cyanocobalamin 12 ug Iron (Iron) Iron 60 mg

Inactive Ingredients Ingredient Name Strength polyethylene glycols   calcium carbonate   povidone   cellulose, microcrystalline   croscarmellose sodium   titanium dioxide   magnesium silicate   vitamin a palmitate   magnesium stearate   ethyl vanillin   Dimethylaminoethyl methacrylate - butyl methacrylate - methyl methacrylate copolymer

Product Characteristics Color WHITE Score no score Shape OVAL Size 14mm Flavor Imprint Code N1 Contains

Packaging # NDC Package Description Multilevel Packaging 1 0178-0716-90 90 TABLET In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
Unapproved drug other		08/25/2011

Labeler - Mission Pharmacal Company (008117095)

Establishment
Name	Address	ID/FEI	Operations
Mission Pharmacal Company		927726893	MANUFACTURE

Revised: 08/2011Mission Pharmacal Company

More NataFort Tablets resources

• NataFort Tablets Use in Pregnancy & Breastfeeding
• Drug Images
• NataFort Tablets Drug Interactions
• NataFort Tablets Support Group
• 21 Reviews for NataForts - Add your own review/rating

Compare NataFort Tablets with other medications

• Vitamin/Mineral Supplementation during Pregnancy/Lactation

Excedrin Tension Headache

Generic Name: acetaminophen and caffeine (a SEET a MIN oh fen and KAF een)

Brand Names: Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra

What is Excedrin Tension Headache (acetaminophen and caffeine)?

Acetaminophen is a pain reliever and a fever reducer.

Caffeine is used in this product to increase the pain relieving effects of acetaminophen.

The combination of acetaminophen and caffeine is used to treat pain from conditions such as headache, muscle aches, menstrual cramps, arthritis, backache, toothaches, colds and fevers.

Acetaminophen and caffeine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Excedrin Tension Headache (acetaminophen and caffeine)?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What should I discuss with my healthcare provider before taking Excedrin Tension Headache (acetaminophen and caffeine)?

Do not take this medication if you are allergic to acetaminophen (Tylenol) or caffeine. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have kidney or liver disease, or a history of alcoholism.

It is not known whether this medicine will harm an unborn baby. Do not take acetaminophen and caffeine without medical advice if you are pregnant. Acetaminophen and caffeine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Excedrin Tension Headache (acetaminophen and caffeine)?

Use this medication exactly as directed on the label, or as prescribed by your doctor.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

One acetaminophen and caffeine pill contains 500 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

The orally disintegrating tablet (Excedrin QuickTabs) should be placed directly on the tongue. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, especially if you still have a fever after 3 days of using this medication, or pain after 10 days of use. Stop taking acetaminophen and caffeine and call your doctor at any time if your symptoms get worse.

Acetaminophen may cause false urine glucose test results. Talk to your doctor if you have diabetes and you notice changes in glucose test results while taking acetaminophen and caffeine.

Store at room temperature away from heat and moisture.

What happens if I miss a dose?

Since acetaminophen and caffeine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include loss of appetite, confusion, nausea, vomiting, diarrhea, sweating, fast or uneven heart rate, seizure (convulsions), pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking Excedrin Tension Headache (acetaminophen and caffeine)?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

Excedrin Tension Headache (acetaminophen and caffeine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using acetaminophen and caffeine and call your doctor at once if you have a serious side effect such as:

• 
  

  low fever with nausea, stomach pain, and loss of appetite;

  
  


• 
  

  dark urine, clay-colored stools; or

  
  


• 
  

  jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  sleep problems (insomnia); or

  
  


• 
  

  feeling nervous, irritable, or jittery.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Excedrin Tension Headache (acetaminophen and caffeine)?

There may be other drugs that can interact with acetaminophen and caffeine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Excedrin Tension Headache resources

• Excedrin Tension Headache Side Effects (in more detail)
• Excedrin Tension Headache Use in Pregnancy & Breastfeeding
• Excedrin Tension Headache Drug Interactions
• Excedrin Tension Headache Support Group
• 2 Reviews for Excedrin Tension Headache - Add your own review/rating

Compare Excedrin Tension Headache with other medications

• Cold Symptoms
• Headache
• Osteoarthritis
• Pain
• Period Pain
• Sinusitis

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and caffeine.

See also: Excedrin Tension Headache side effects (in more detail)